Extracellular environment and cellular responses
Cells not only receive genetic cues encoded by genome but also external cues derived from microenvironment and respond by altering cytoskeletal organization and cellular functions, thereby maintaining homeostasis. Our group is interested in the component of extracellular microenvironment, particularly extracellular matrix (ECM) proteins in the vessel wall, and we study what their biological functions are and how they interact with cells.
Extracellular environment and cellular responses in development and disease
Hiromi Yanagisawa, M.D., Ph.D. (Professor, TARA Center)
By taking molecular, biochemical, and genetic engineering approaches, we study the role of ECM proteins during development and diseases and their potential contributions to adult stem cell niche.